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KMID : 1123920020160020279
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 2 p.279 ~ p.288
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The Effects of Crataegus pinnatifida BGE. var. major N.E. BR Extract on the Alzheimer’s Disease Model
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Jung In-Chul
Lee Sang-Ryong
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Abstract
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This research investigates the effect of the Crataegus pinnatifida BGE. var. major N.E. BR(CPVM) on Alzheimer’s disease. The CPVM extract suppressed the expression of IL-1 β, IL-6, APP, AChE mRNA in PC-12 cells treated with CT105. The CPVM extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT105. The CPVM extract group showed a significant inhibitory effect on the memory deficit for the mice with Alzheimer’s disease induced by CT105 in the Morris water maze experiment. The CPVM extract suppressed the over-expression of IL-1 β, TNF- α and ROS in the mice with Alzheimer’s disease induced by CT105. This study suggests that CPVM may be effective for the prevention and treatment of Alzheimer’s disease.
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KEYWORD
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Crataegus pinnatifida BGE. var. major N.E. BR, Dementia, Alzheimer’s disease, CT105, amyloid precursor proteins, cytokine, acetylcholinesterase
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